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As a general rule: if you have known pre-existing conditions or regularly take medications, consultation with a doctor or pharmacist before taking milk thistle preparations is essential

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Importantly, elevated 4-HNE levels have been reported in β-cells from DIO rodents, in islets from db/db diabetic mice, and in islets of T2D human cadaveric donors (158, 165, 174–176), suggesting of increased islet PC in T2D